Deletion of EFG1 promotes Candida albicans opaque formation responding to pH via Rim101
نویسندگان
چکیده
منابع مشابه
Hypha formation in the white-opaque transition of Candida albicans.
Cells of Candida albicans strain WO-1 and related strains switch frequently and reversibly between a white-colony-forming unit (white phase) and a gray-colony-forming unit (opaque phase). Cells in the budding white phase exhibit the usual smooth round phenotype observed in other C. albicans strains, but cells in the budding opaque phase exhibit a unique elongate shape with surface pimples or pr...
متن کاملInvestigation the expression Candida albicans EFG1 gene in Vaginal Candidiasis and biofilm formation
Candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. Efg1gene of C.albicans is as a main transcription factor that plays pivotal roles in biofilm formation The aim of the current study is to investigate the presence of Efg1 gene in Candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.We us...
متن کاملDominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans.
Morphological development of the fungal pathogen Candida albicans is profoundly affected by ambient pH. Acidic pH restricts growth to the yeast form, whereas neutral pH permits development of the filamentous form. Superimposed on the pH restriction is a temperature requirement of approximately 37 degrees C for filamentation. The role of pH in development was investigated by selecting revertants...
متن کاملCandida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death.
Quorum sensing by farnesol in Candida albicans inhibits filamentation and may be directly related to its ability to cause both mucosal and systemic diseases. The Ras1-cyclic AMP signaling pathway is a target for farnesol inhibition. However, a clear understanding of the downstream effectors of the morphological farnesol response has yet to be unraveled. To address this issue, we screened a libr...
متن کاملRIM101-dependent and-independent pathways govern pH responses in Candida albicans.
Growth and differentiation of Candida albicans over a broad pH range underlie its ability to infect an array of tissues in susceptible hosts. We identified C. albicans RIM101, RIM20, and RIM8 based on their homology to components of the one known fungal pH response pathway. PCR product-disruption mutations in each gene cause defects in three responses to alkaline pH: filamentation, induction of...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2010
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmq076